Cerebrospinal fluid pressure and glaucomatous optic disc cupping

Clinical characteristics of nonglaucomatous optic disc cupping

Pathological optic disc cupping (ODC) is predominantly referred to as glaucoma; however, it is not only glaucoma that leads to pathological optic disc excavation. A number of other nonglaucomatous diseases also result in optic atrophy and excavation of the optic disc. Therefore, in the present study, the etiology of nonglaucomatous optic disc cupping (NGODC) was analyzed and differentiated from...

Pathogenesis of cupping of the optic disc.

Optic disc movement with variations in intraocular and cerebrospinal fluid pressure.

PURPOSE To determine the effect of intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) on optic disc movement and lamina cribrosa displacement using confocal scanning laser tomography (CSLT). METHODS The anterior chamber and lateral ventricles were cannulated in mixed-breed dogs (n = 8) to allow modulation and control of IOP and CSFP, respectively. Optic disc topography was det...

Pathogenesis of cupping of the optic disc

Optic disc cupping (ODC) is a classical feature of chronic simple glaucoma. In attempts to explain the pathogenesis of ODC, a very large volume of literature has accumulated since its discovery over I 20 years ago, but the mechanism is still far from clear. The presence of ODC with no rise in intraocular pressure (IOP), first described by von Graefe (I857), has further contributed to the confus...

Colobomatous cupping of the optic disc.

Coloboma confined to the optic disc is a relatively rare condition (Steinberg, 1943), and has been described as unilateral in the majority of cases (Duke-Elder, I964; FranSois, I964). However, manifestation of the deformity may occur in the other eye (Hughes, 1947), and a number of bilateral cases have now been described. This paper records another bilateral case. A 35-year-old man was found to...